`Dorothy Mary Crowfoot Hodgkin` Biography - Nobel Prize Winner (1964)

Dorothy Mary Crowfoot Hodgkin, OM , FRS (May 12, 1910 – July 29, 1994) was a British founder of protein crystallography. She pioneered the technique of X-ray crystallography, a method used to determine the three dimensional structures of biomolecules. Among her most influential discoveries are the determination of the structure of penicillin, insulin, and vitamin B12 for which she was awarded the Nobel Prize in Chemistry. Besides her extraordinary scientific abilities, she was unassuming, very communicative, and passionate about social inequalities and peace.

Timeline of her discoveries Hodgkin determined the three-dimensional structures of the following biomolecules: cholesterol in 1937 penicillin in 1945 vitamin B12 in 1954 insulin in 1969 as well as lactoglobulin, ferritin, and tobacco mosaic virus The list is not exhaustive, it rather highlights major milestones. Early years She was born Dorothy Mary Crowfoot in 1910 in Cairo, Egypt, to John Crowfoot, excavator and scholar of classics, and Grace Mary Crowfoot née Hood. For the first four years of her life she lived as an English expatriate in Asia Minor, returning to England only a few months each year. She spent the period of World War I in the UK under the care of relatives and friends, but separated from her parents. After the war, her mother decided to stay home in England and educate her children - a period that Hodgkin later described as the happiest in her life. In 1921, she entered the Leman School. She traveled abroad frequently to visit her parents in Cairo and Khartoum. Both her father and her mother had a strong influence with their Puritan ethic of selflessness and service to humanity which reverberated in her later achievements. Education and research Dorothy Hodgkin with a ball-stick representation of insulin, courtesy of Pugwash Conferences on Science & World AffairsShe developed a passion for chemistry from a young age, and her mother fostered her interest in science in general. Her excellent early education prepared her well for university. Aged 18, she started studying chemistry at Somerville College, Oxford, then one of the Oxford University colleges for women only. She also studied at Cambridge University under the tutelage of John Desmond Bernal, where she became aware of the potential of X-ray crystallography to determine the structure of proteins. In 1934, she moved back to Oxford and two years later, in 1936, she became a research fellow at Somerville College, Oxford, a post which she held until 1977. In 1960 she was appointed Wolfson Research Professor at the Royal Society. Insulin structure Insulin was one of her extraordinary research projects. It began in 1934 when she was offered a small sample of crystalline insulin by Robert Robinson. The hormone captured her imagination because of the intricate and wide-ranging effect it has in the body. However, at this stage X-ray crystallography had not been developed far enough to cope with the complexity of the insulin molecule. She and others spent many years improving the technique. Larger and more complex molecules were being tackled (see timeline above) until in 1969 - 35 years later - the structure of insulin was finally resolved. But her quest was not finished then. She cooperated with other laboratories active in insulin research, gave advice, and travelled the world giving talks about insulin and its importance for diabetes. She considered solving the structure of insulin her greatest scientific achievement. Private life Hodgkin's scientific mentor J.D. Bernal greatly influenced her life both scientifically and politically. He was a distinguished scientist of great repute in the scientific world, a member of the Communist party, and a faithful supporter of successive Soviet regimes until their invasion of Hungary. She always referred to him as "Sage" and loved and admired him unreservedly; intermittently, they were lovers. The conventional marriages of both Bernal and Hodgkin were far from smooth. In 1937, Dorothy married Thomas Hodgkin who was also a one-time member of the Communist party, as well as a charming, intelligent, energetic and impulsive suitor. She also loved him and always consulted him concerning important problems and decisions. Dorothy bore quietly the many difficulties of these situations. He later had a checkered and varied career as a schoolteacher, worker's educationist, historian and economist. He became an advisor in 1961 to Kwame Nkrumah, President of Ghana, where he remained for extended periods, often visited by her. The couple had three children. Social activities Despite her scientific specialisation and excellence she was by no means a single-minded and one-sided scientist. She received many honours but was more interested in exchange with other scientists. She often employed her intelligence to think about other people's problems and was concerned about social inequalities and stopping conflict. As a consequence she was President of Pugwash from 1976 to 1988. Honours Order of Merit medal of Dorothy Crowfoot Hodgkin, displayed in the Royal Society, LondonIn 1964 she was awarded the Nobel Prize in Chemistry for her work in crystallography and in 1976 the Copley Medal from the Royal Society. In 1965 she was appointed to the Order of Merit, filling the vacancy left by Winston Churchill. In 1985-6 she was awarded the Lenin Peace Prize. She was Chancellor of Bristol University from 1970 to 1988.

LIST OF NOBEL PRIZE WINNERS IN CHEMISTRY PART II.

Grignard Victor

Grubbs Robert H

Haber Fritz

Harden Sir Arthur

Hauptman Herbert

Sir Walter Norman Haworth

Herschbach Dudley

Herzberg Gerhard

Heyrovsky Jaroslav

Hinshelwood Sir Cyril Norman

Hodgkin Dorothy Crowfoot

Hoff Jacobus Henricus

Joliot-Curie Irene

Joliot Frederic

Kendrew Sir John Cowdery

Knowles William

Kroto Sir Harold

Langmuir Irving

Lehn Jean-Marie

Libby Willard Frank

Lipscomb William

MacDiarmid Alan G

MacKinnon Roderick

Marcus Rudolph A

Martin Archer John Porter

McMillan Edwin Mattison

Merrifield Robert Bruce

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